In this article, we discuss a hypothesis to explain the preferential synthesis of the superoxide sensitive form of aconitase in mitochondria and the phenotype observed in manganese superoxide dismutase mutant mice, which show a gross over accumulation of stored fat in liver. The model proposes that intermediary metabolism is redox regulated by mitochondrial superoxide generated during mitochondrial respiration. This regulates the level of reducing equivalents (NADH) entering the electron transport chain (ETC) through the reversible inactivation of mitochondrial aconitase. This control (...) mechanism has a dual function; firstly, it regulates levels of superoxide generated by the ETC and, secondly, it fine‐tunes metabolism by channeling citrate either for the production of NADH for energy metabolism or diverting it for the synthesis of fats. In this setting, the mitochondrial redox state influences metabolic decisions via a superoxide–aconitase rheostat. BioEssays 26:894–900, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Although the prevalence of facial recognition-based COVID-19 surveillance tools and techniques, China does not have a facial recognition law to protect its residents’ facial data. Oftentimes, neither the public nor the government knows where people’s facial images are stored, how they have been used, who might use or misuse them, and to what extent. This reality is alarming, particularly factoring in the wide range of unintended consequences already caused by good-intentioned measures and mandates amid the pandemic. Biometric data are matters (...) of personal rights and national security. In light of worrisome technologies such as deep-fake pornography, the protection of biometric data is also central to the protection of the dignity of the citizens and the government, if not the industry as well. This paper discusses the urgent need for the Chinese government to establish rigorous and timely facial recognition laws to protect the public’s privacy, security, and dignity amid COVID-19 and beyond. (shrink)

Despite a large and multifaceted effort to understand the vast landscape of phenotypic data, their current form inhibits productive data analysis. The lack of a community-wide, consensus-based, human- and machine-interpretable language for describing phenotypes and their genomic and environmental contexts is perhaps the most pressing scientific bottleneck to integration across many key fields in biology, including genomics, systems biology, development, medicine, evolution, ecology, and systematics. Here we survey the current phenomics landscape, including data resources and handling, and the progress that (...) has been made to accurately capture relevant data descriptions for phenotypes. We present an example of the kind of integration across domains that computable phenotypes would enable, and we call upon the broader biology community, publishers, and relevant funding agencies to support efforts to surmount today's data barriers and facilitate analytical reproducibility. (shrink)

This article details day-to-day ethics issues facing MBAs who occupy entry-level and mid-level management positions and offers defined examples of the stressors these managers face. The study includes lower-level managers, essentially excluded from extant literature, and focuses on workplace behaviors both undertaken and observed. Results indicate that pressures from internal organization sources, and ambiguity in letter versus spirit of rules, account for over a third of the most frequent unethical situations encountered, and that most managers did not expect to face (...) those issues. Various contextual factors accounted for 32% of the organizational factors that affected decisions. We discuss implications for the workplace, especially the unique ethics challenges for newer managers. (shrink)

This article details day-to-day ethics issues facing MBAs who occupy entry-level and mid-level management positions and offers defined examples of the stressors these managers face. The study includes lower-level managers, essentially excluded from extant literature, and focuses on workplace behaviors both undertaken and observed. Results indicate that pressures from internal organization sources, and ambiguity in letter versus spirit of rules, account for over a third of the most frequent unethical situations encountered, and that most managers did not expect to face (...) those issues. Various contextual factors accounted for 32% of the organizational factors that affected decisions. We discuss implications for the workplace, especially the unique ethics challenges for newer managers. (shrink)

This book provides practical and research-based chapters that offer greater clarity about the particular kinds of teacher reflection that matter and avoids talking about teacher reflection generically, which implies that all kinds of reflection are of equal value.

Research using mHealth apps has the potential to positively impact health care management and outcomes. However, choosing an appropriate mHealth app may be challenging for the health researcher. The author team used existing evaluation tools, checklists, and guidelines to assess selected mHealth apps to identify strengths, challenges, and potential gaps within existing evaluation tools. They identified specific evaluation tool components, questions, and items most effective in examining app content, usability, and features, including literacy demand and cultural appropriateness; technical information; practical (...) aspects of app functionality; and evolving capabilities of mobile medical apps. Challenges included the subjective nature of the results, time required to complete the evaluation, lack of emphasis on evidence‐based content, and inadequate tool flexibility. Health researchers considering the integration of mobile apps into research will benefit from evaluation tools that assess both evidence‐based content and the ability of the mobile app to securely integrate with other digital technologies involved in patient care. Next steps will include the involvement of health care providers and professionals, including nurses a wide range of expertise, to develop an mHealth evaluation tool that focuses on identifying quality, evidence‐based mobile apps into patient outcomes research. (shrink)

The US neutrino community gathered at the Workshop on the Intermediate Neutrino Program at Brookhaven National Laboratory February 4-6, 2015 to explore opportunities in neutrino physics over the next five to ten years. Scientists from particle, astroparticle and nuclear physics participated in the workshop. The workshop examined promising opportunities for neutrino physics in the intermediate term, including possible new small to mid-scale experiments, US contributions to large experiments, upgrades to existing experiments, R&D plans and theory. The workshop was organized into (...) two sets of parallel working group sessions, divided by physics topics and technology. Physics working groups covered topics on Sterile Neutrinos, Neutrino Mixing, Neutrino Interactions, Neutrino Properties and Astrophysical Neutrinos. Technology sessions were organized into Theory, Short-Baseline Accelerator Neutrinos, Reactor Neutrinos, Detector R&D and Source, Cyclotron and Meson Decay at Rest sessions.This report summarizes discussion and conclusions from the workshop. (shrink)

Integrity is a critical determinant of the effectiveness of research organizations in terms of producing high quality research and educating the new generation of scientists. A number of responsible conduct of research (RCR) training programs have been developed to address this growing organizational concern. However, in spite of a significant body of research in ethics training, it is still unknown which approach has the highest potential to enhance researchers’ integrity. One of the approaches showing some promise in improving researchers’ integrity (...) has focused on the development of ethical decision-making skills. The current effort proposes a novel curriculum that focuses on broad metacognitive reasoning strategies researchers use when making sense of day-to-day social and professional practices that have ethical implications for the physical sciences and engineering. This sensemaking training has been implemented in a professional sample of scientists conducting research in electrical engineering, atmospheric and computer sciences at a large multi-cultural, multi-disciplinary, and multi-university research center. A pre-post design was used to assess training effectiveness using scenario-based ethical decision-making measures. The training resulted in enhanced ethical decision-making of researchers in relation to four ethical conduct areas, namely data management, study conduct, professional practices, and business practices. In addition, sensemaking training led to researchers’ preference for decisions involving the application of the broad metacognitive reasoning strategies. Individual trainee and training characteristics were used to explain the study findings. Broad implications of the findings for ethics training development, implementation, and evaluation in the sciences are discussed. (shrink)

ABSTRACTPresenting information in a coherent fashion has been shown to increase processing fluency, which in turn influences affective responses. The pattern of responses have been explained by two...

© 2015, Springer-Verlag Berlin Heidelberg.Genetic studies have identified single nucleotide polymorphisms associated with the risk of prostate cancer. It remains unclear whether such genetic variants are associated with disease aggressiveness. The NCI-SPORE Genetics Working Group retrospectively collected clinicopathologic information and genotype data for 36 SNPs which at the time had been validated to be associated with PC risk from 25,674 cases with PC. Cases were grouped according to race, Gleason score and aggressiveness. Statistical analyses were used to compare the frequency (...) of the SNPs between different disease cohorts. After adjusting for multiple testing, only PC-risk SNP rs2735839 was significantly and inversely associated with aggressive and high-grade disease in European men. Similar associations with aggressive and high-grade disease were documented in African-American subjects. The G allele of rs2735839 was associated with disease aggressiveness even at low PSA levels in both European and African-American men. Our results provide further support that a PC-risk SNP rs2735839 near the KLK3 gene on chromosome 19q13 may be associated with aggressive and high-grade PC. Future prospectively designed, case-case GWAS are needed to identify additional SNPs associated with PC aggressiveness. (shrink)

Background: People with traumatic brain injury face a range of mental health challenges during the adjustment process post-injury, but access to treatment can be difficult, particularly for those who live in regional and remote regions. eHealth provides the potential to improve access to evidence-based psychological therapy for people with a severe TBI. The aim of the current study is to assess the efficacy of a psychological intervention delivered via video consulting to reduce psychological distress in people with TBI.Methods: This paper (...) outlines the protocol for a multi-center, three-arm, parallel, non-inferiority randomized controlled trial of an evidence-based manualized psychological intervention, ACT-Adjust. ACT-Adjust provides nine sessions for adults with a moderate to severe TBI experiencing clinical levels of psychological distress. Fifty-six participants referred from Brain Injury Rehabilitation Units across New South Wales and the NSW icare scheme will be randomly allocated to three conditions; video consulting, face-to-face and, a waitlist control.Discussion: This is the first RCT to evaluate the efficacy of a psychological therapy delivered via video consulting for individuals with a moderate to severe TBI.Trial Registration:www.anzctr.org.au, Australian New Zealand Clinical Trials Registry ANZCTRN2619001602112. (shrink)

Tom Andersen’s reflecting team process, which allowed families to witness and respond to the talk of professionals during therapy sessions, has been described as revolutionary in the field of family therapy. Reflecting teams are prominent in a number of family therapy approaches, more recently in narrative and dialogical therapies. This way of working is considered more a philosophy than a technique, and has been received positively by both therapists and service users. This paper describes how dialogical therapists conceptualise the reflective (...) process, how they work to engage families in reflective dialogues and how this supports change. We conducted semi-structured, reflective interviews with 12 dialogical therapists with between 2 and 20 years of experience. Interpretative Phenomenological analysis of transcribed interviews identified varying conceptualisations of the reflecting process and descriptions of therapist actions that support reflective talk among network members. We adopted a dialogical approach to interpretation of this data. In this sense, we did not aim to condense accounts into consensus but instead to describe variations and new ways of understanding dialogical reflecting team practices. Four themes were identified: Lived experience as expertise; Listening to the self and hearing others; Relational responsiveness and fostering connection; and Opening space for something new. We applied these themes to psychotherapy process literature both within family therapy literature and more broadly to understand more about how reflecting teams promote helpful and healing conversations in practice. (shrink)

pThis paper examines Nishida Kitarō’s (1870–1945) late essay, “Life,” which develops the process of “world-expression” (世界表現) to situate human and nonhuman agency in ways drawing his thought closer to concerns of posthuman ideals of inter-species commensurability and biosemiotics today. Here he extends his philosophy of a site-specific matrix or basho (場所) so as to incorporate arguments from J. S. Haldane’s emThe Philosophical Basis of Biology/em (1931), which poses questions concerning the coordination of organisms and environments. Nishida finds in Haldane support (...) for his own situating of selves, even engaging questions concerning how animals count as selves./p. (shrink)

Quantitative researchers often discuss research ethics as if specific ethical problems can be reduced to abstract normative logics (e.g., virtue ethics, utilitarianism, deontology). Such approaches overlook how values are embedded in every aspect of quantitative methods, including ‘observations,’ ‘facts,’ and notions of ‘objectivity.’ We describe how quantitative research practices, concepts, discourses, and their objects/subjects of study have always been value-laden, from the invention of statistics and probability in the 1600s to their subsequent adoption as a logic made to appear as (...) if it exists prior to, and separate from, ethics and values. This logic, which was embraced in the Academy of Management from the 1960s, casts management researchers as ethical agents who ought to know about a reality conceptualized as naturally existing in the image of statistics and probability (replete with ‘constructs’), while overlooking that S&P logic and practices, which researchers made for themselves, have an appreciable role in making the world appear this way. We introduce a different way to conceptualize reality and ethics, wherein the process of scientific inquiry itself requires an examination of its own practices and commitments. Instead of resorting to decontextualized notions of ‘rigor’ and its ‘best practices,’ quantitative researchers can adopt more purposeful ways to reason about the ethics and relevance of their methods and their science. We end by considering implications for addressing ‘post truth’ and ‘alternative facts’ problems as collective concerns, wherein it is actually the pluralistic nature of description that makes defending a collectively valuable version of reality so important and urgent. (shrink)

The goal of this paper is to explore the significance of Montague’s paradox—that is, any arithmetical theory $T\supseteq Q$ over a language containing a predicate $P$ satisfying $P\rightarrow \varphi $ and $T\vdash \varphi \,\therefore\,T\vdash P$ is inconsistent—as a limitative result pertaining to the notions of formal, informal, and constructive provability, in their respective historical contexts. To this end, the paradox is reconstructed in a quantified extension $\mathcal {QLP}$ of Artemov’s logic of proofs. $\mathcal {QLP}$ contains both explicit modalities $t:\varphi $ (...) and also proof quantifiers $x:\varphi $. In this system, the basis for the rule NEC is decomposed into a number of distinct principles governing how various modes of reasoning about proofs and provability can be internalized within the system itself. A conceptually motivated resolution to the paradox is proposed in the form of an argument for rejecting the unrestricted rule NEC on the basis of its subsumption of an intuitively invalid principle pertaining to the interaction of proof quantifiers and the proof-theorem relation expressed by explicit modalities. (shrink)

Un Siècle d'antiféminisme est l'un des premiers travaux universitaires s'attachant à définir l'antiféminisme et à en retracer l'historique en France au cours des cent dernières années. Son intérêt repose sur l'éventail et la variété des contributions réunies par Christine Bard autour de trois axes : « De la fin du XIXe siècle aux années folles », « Des années 1930 au baby boom » et « Du MLF à nos jours ». Il rend compte non seulement de la véritable bataille (...) contre les droits politique... (shrink)

Christine Bard, avec Les Garçonnes, propose un fougueux antidote à la remarquable capacité du patriarcat à convertir la rébellion féminine en un reflet de son propre désir ou anxiété. Dans une analyse extrêmement précise de la garçonne, l'auteur montre combien cette figure est essentiellement une métaphore de la dissolution des mœurs. La garçonne rejette la féminité traditionnelle, s'attirant la colère de ceux qu'inquiète la dépopulation. Son corps échappe aux bornes érigées par les co..

Christine Bard, avec Les Garçonnes, propose un fougueux antidote à la remarquable capacité du patriarcat à convertir la rébellion féminine en un reflet de son propre désir ou anxiété. Dans une analyse extrêmement précise de la garçonne, l'auteur montre combien cette figure est essentiellement une métaphore de la dissolution des mœurs. La garçonne rejette la féminité traditionnelle, s'attirant la colère de ceux qu'inquiète la dépopulation. Son corps échappe aux bornes érigées par les co...

Computational complexity theory is a subfield of computer science originating in computability theory and the study of algorithms for solving practical mathematical problems. Amongst its aims is classifying problems by their degree of difficulty — i.e., how hard they are to solve computationally. This paper highlights the significance of complexity theory relative to questions traditionally asked by philosophers of mathematics while also attempting to isolate some new ones — e.g., about the notion of feasibility in mathematics, the $\mathbf{P} \neq \mathbf{NP}$ (...) problem and why it has proven hard to resolve, and the role of non-classical modes of computation and proof. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Materialities of CommunicationEric DeanThe Materialities of Communication, edited by Hans Ulrich Gumbrecht and K. Ludwig Pfeiffer; xvi & 447pp. Stanford: Stanford University Press, 1994, $52.50 cloth, $17.95 paper.In closing this collection, Hans Ulrich Gumbrecht outlines the common purpose which makes it more than a random assortment. There has been, as he characterizes it, a theoretical shift in the humanities “from interpretation as identification of given meaning-structures to (...) the reconstruction of those processes through which structures of articulated meaning can at all emerge” (p. 398). He motivates this shift by suggesting that theorists should no longer pursue final and therefore unchanging explanations, but rather should create provocations for changes in perspective. Focusing on the processes through which meaning can emerge—the materialities of communication rather than the insubstantialities of interpretation—stimulates the constant change, the perpetual “renegotiation of self-reference,” which Gumbrecht recommends as the rightful role of theory.The breadth of these ambitions is reflected in the scope of the collection. There are twenty-five essays from twenty-six writers, predominately German, including two from each editor—a context piece and a separate contribution. The range of subjects is enormous. There is one essay on ancient Egyptian signs and another on how the immune system creates the self it both recognizes and preserves. One touches on Nietzsche’s abortive attempt to save his eyesight by using an early version of the typewriter, another interprets the fall of the Roman Empire as the corruption of the postal system (Egyptian in origin) used to deliver the command, imperium, which constituted the Empire in the first place. The scholarly contexts range widely as well—from sociological communication theory to media history to biology to art criticism.There are some delightful curiosities the writers bring to light. For example, at one point in “The Early History of German Television,” the authors, M. Elsner, T. Muller, and P. Spangenberg are describing how fantasies about the new technology outran practicalities. They cite an illustration from a 1928 German magazine in which a man is shown lying in bed, “with a fragmented dashboard in front of him—he seems to steer some technical apparatus and, at the same time, to look at a mountain panorama, which is seen from a bird’s eye view on a kind of projection screen. The caption deciphers the illustration for us: ‘Marvels that we might still experience: viewing the world from bed through [End Page 395] television. The apparatus above the bed serves to operate, by remote control, an airplane that carries the filming apparatus...’” (p. 117).In other places too the writing evades the risk of self-absorption implicit, for all its purportedly exterior focus, in Gumbrecht’s theoretical project. Vivian Sobchack, for instance, closes an interesting meditation on film and electronic technologies this way: “Within the context of this material and technological crisis of the flesh, one can only hope that the hysteria and hyperbole surrounding it is strategic—and that through it the lived-body has, in fact, managed to reclaim its existence and against our attention, to forcefully argue for simulation. For there are other subjects of electronic culture out there who prefer the simulated body and a virtual world...” (pp. 105–6).By the end, though, I found myself wondering whether it was really possible to put this diversity together as a whole, whether the purportedly redeeming concreteness of a program focused on The Materialities of Communication wasn’t at odds with the idea that there is much in common among all these different materials. Coeditor K. Ludwig Pfeiffer, may have inadvertently provided the epigraph for the book. “Iago incites Othello to the greatest nonsense,” he writes, “because Othello no longer differentiates between manipulated sensual certainty and credibility” (p. 59). I wonder about a theoretical perspective that calls Othello’s torment his “nonsense,” and I wonder whether the advocates of such a perspective might not be manipulating sensual certainty to perhaps equally bleak, though in this case unintended, ends.Eric DeanChicago, IllinoisCopyright © 1995 The Johns Hopkins University Press... (shrink)